Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling to Predict the Impact of CYP2C9 Genetic Polymorphisms, Co-Medication and Formulation on the Pharmacokinetics and Pharmacodynamics of Flurbiprofen

Physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) models can serve as a powerful framework for predicting the influence as well as the interaction of formulation, genetic polymorphism and co-medication on the pharmacokinetics and pharmacodynamics of drug substances. In this study, flur...

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Hoofdauteurs: Ioannis Loisios-Konstantinidis (Auteur), Rodrigo Cristofoletti (Auteur), Masoud Jamei (Auteur), David Turner (Auteur), Jennifer Dressman (Auteur)
Formaat: Boek
Gepubliceerd in: MDPI AG, 2020-11-01T00:00:00Z.
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