Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling to Predict the Impact of CYP2C9 Genetic Polymorphisms, Co-Medication and Formulation on the Pharmacokinetics and Pharmacodynamics of Flurbiprofen

• मुख्य लेखकों: Ioannis Loisios-Konstantinidis (लेखक), Rodrigo Cristofoletti (लेखक), Masoud Jamei (लेखक), David Turner (लेखक), Jennifer Dressman (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2020-11-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) models can serve as a powerful framework for predicting the influence as well as the interaction of formulation, genetic polymorphism and co-medication on the pharmacokinetics and pharmacodynamics of drug substances. In this study, flur...