Time course of altered sensitivity to inhibitory and excitatory agonist responses in the longitudinal muscle-myenteric plexus and analgesia in the guinea pig after chronic morphine treatment

• Main Authors: Dane M Barrett (Author), Hercules Tarambirwa Maguma (Author), David A Taylor (Author)
• Formato: Libro
• Publicado: Frontiers Media S.A., 2012-01-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Tolerance that develops after chronic morphine exposure has been proposed to be an adaptive response that develops and decays over a defined time course. The present study examined the development of tolerance to the acute hypothermic and analgesic effects of morphine and correlated the time course...