Time course of altered sensitivity to inhibitory and excitatory agonist responses in the longitudinal muscle-myenteric plexus and analgesia in the guinea pig after chronic morphine treatment

• Glavni autori: Dane M Barrett (Autor), Hercules Tarambirwa Maguma (Autor), David A Taylor (Autor)
• Format: Knjiga
• Izdano: Frontiers Media S.A., 2012-01-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Tolerance that develops after chronic morphine exposure has been proposed to be an adaptive response that develops and decays over a defined time course. The present study examined the development of tolerance to the acute hypothermic and analgesic effects of morphine and correlated the time course...