2-Hydroxy-3-methylanthraquinone inhibits homologous recombination repair in osteosarcoma through the MYC-CHK1-RAD51 axis

• 主要な著者: Doudou Jing (著者), Xuanzuo Chen (著者), Zhenhao Zhang (著者), Fengxia Chen (著者), Fuhua Huang (著者), Zhicai Zhang (著者), Wei Wu (著者), Zengwu Shao (著者), Feifei Pu (著者)
• フォーマット: 図書
• 出版事項: BMC, 2023-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Abstract Background Osteosarcoma is a malignant bone tumor that usually affects adolescents aged 15-19 y. The DNA damage response (DDR) is significantly enhanced in osteosarcoma, impairing the effect of systemic chemotherapy. Targeting the DDR process was considered a feasible strategy benefitting o...