2-Hydroxy-3-methylanthraquinone inhibits homologous recombination repair in osteosarcoma through the MYC-CHK1-RAD51 axis

• Main Authors: Doudou Jing (Author), Xuanzuo Chen (Author), Zhenhao Zhang (Author), Fengxia Chen (Author), Fuhua Huang (Author), Zhicai Zhang (Author), Wei Wu (Author), Zengwu Shao (Author), Feifei Pu (Author)
• Format: Book
• Published: BMC, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Osteosarcoma is a malignant bone tumor that usually affects adolescents aged 15-19 y. The DNA damage response (DDR) is significantly enhanced in osteosarcoma, impairing the effect of systemic chemotherapy. Targeting the DDR process was considered a feasible strategy benefitting o...