2-Hydroxy-3-methylanthraquinone inhibits homologous recombination repair in osteosarcoma through the MYC-CHK1-RAD51 axis

Abstract Background Osteosarcoma is a malignant bone tumor that usually affects adolescents aged 15-19 y. The DNA damage response (DDR) is significantly enhanced in osteosarcoma, impairing the effect of systemic chemotherapy. Targeting the DDR process was considered a feasible strategy benefitting o...

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主要な著者: Doudou Jing (著者), Xuanzuo Chen (著者), Zhenhao Zhang (著者), Fengxia Chen (著者), Fuhua Huang (著者), Zhicai Zhang (著者), Wei Wu (著者), Zengwu Shao (著者), Feifei Pu (著者)
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出版事項: BMC, 2023-01-01T00:00:00Z.
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3rd Floor Main Library

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