2-Hydroxy-3-methylanthraquinone inhibits homologous recombination repair in osteosarcoma through the MYC-CHK1-RAD51 axis

• Hoofdauteurs: Doudou Jing (Auteur), Xuanzuo Chen (Auteur), Zhenhao Zhang (Auteur), Fengxia Chen (Auteur), Fuhua Huang (Auteur), Zhicai Zhang (Auteur), Wei Wu (Auteur), Zengwu Shao (Auteur), Feifei Pu (Auteur)
• Formaat: Boek
• Gepubliceerd in: BMC, 2023-01-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Abstract Background Osteosarcoma is a malignant bone tumor that usually affects adolescents aged 15-19 y. The DNA damage response (DDR) is significantly enhanced in osteosarcoma, impairing the effect of systemic chemotherapy. Targeting the DDR process was considered a feasible strategy benefitting o...