Reduced off-target effect of NG-BE4max by using NG-HiFi system

Recently, a rationally engineered SpCas9 variant (SpCas9-NG) that can recognize a minimal NG protospacer adjacent motif (PAM) was reported to expand the targeting scope in genome editing. However, increased genome-wide off-target mutations with this variant compared with SpCas9 were reported in prev...

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主要な著者: Huanhuan Shan (著者), Zhiquan Liu (著者), Yingqi Jia (著者), Siyu Chen (著者), Mao Chen (著者), Yuning Song (著者), Tingting Sui (著者), Liangxue Lai (著者), Zhanjun Li (著者)
フォーマット: 図書
出版事項: Elsevier, 2021-09-01T00:00:00Z.
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