Enhancing oral bioavailability of andrographolide using solubilizing agents and bioenhancer: comparative pharmacokinetics of Andrographis paniculata formulations in beagle dogs

• Autores principales: Phanit Songvut (Autor), Tussapon Boonyarattanasoonthorn (Autor), Nitra Nuengchamnong (Autor), Thammaporn Junsai (Autor), Teetat Kongratanapasert (Autor), Kittitach Supannapan (Autor), Phisit Khemawoot (Autor)
• Formato: Libro
• Publicado: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

AbstractContext The therapeutic potential of andrographolide is hindered by its poor oral bioavailability and unpredictable pharmacokinetics, primarily due to its limited water solubility.Objective This work aimed to enhance the solubility and pharmacokinetics of andrographolide, a bioactive compoun...