Lacosamide Inhibition of NaV1.7 Channels Depends on its Interaction With the Voltage Sensor Domain and the Channel Pore

• Main Authors: Julie I. R. Labau (Author), Matthew Alsaloum (Author), Mark Estacion (Author), Brian Tanaka (Author), Fadia B. Dib-Hajj (Author), Giuseppe Lauria (Author), Hubert J. M. Smeets (Author), Catharina G. Faber (Author), Sulayman Dib-Hajj (Author), Stephen G. Waxman (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lacosamide, developed as an anti-epileptic drug, has been used for the treatment of pain. Unlike typical anticonvulsants and local anesthetics which enhance fast-inactivation and bind within the pore of sodium channels, lacosamide enhances slow-inactivation of these channels, suggesting different bi...