Lacosamide Inhibition of NaV1.7 Channels Depends on its Interaction With the Voltage Sensor Domain and the Channel Pore

• প্রধান লেখক: Julie I. R. Labau (লেখক), Matthew Alsaloum (লেখক), Mark Estacion (লেখক), Brian Tanaka (লেখক), Fadia B. Dib-Hajj (লেখক), Giuseppe Lauria (লেখক), Hubert J. M. Smeets (লেখক), Catharina G. Faber (লেখক), Sulayman Dib-Hajj (লেখক), Stephen G. Waxman (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Frontiers Media S.A., 2021-12-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Lacosamide, developed as an anti-epileptic drug, has been used for the treatment of pain. Unlike typical anticonvulsants and local anesthetics which enhance fast-inactivation and bind within the pore of sodium channels, lacosamide enhances slow-inactivation of these channels, suggesting different bi...