Lacosamide Inhibition of NaV1.7 Channels Depends on its Interaction With the Voltage Sensor Domain and the Channel Pore

Lacosamide Inhibition of NaV1.7 Channels Depends on its Interaction With the Voltage Sensor Domain and the Channel Pore

Lacosamide, developed as an anti-epileptic drug, has been used for the treatment of pain. Unlike typical anticonvulsants and local anesthetics which enhance fast-inactivation and bind within the pore of sodium channels, lacosamide enhances slow-inactivation of these channels, suggesting different bi...

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Main Authors: Julie I. R. Labau (Author), Matthew Alsaloum (Author), Mark Estacion (Author), Brian Tanaka (Author), Fadia B. Dib-Hajj (Author), Giuseppe Lauria (Author), Hubert J. M. Smeets (Author), Catharina G. Faber (Author), Sulayman Dib-Hajj (Author), Stephen G. Waxman (Author)
Format: Book
Published: Frontiers Media S.A., 2021-12-01T00:00:00Z.
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3rd Floor Main Library

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