Lacosamide Inhibition of NaV1.7 Channels Depends on its Interaction With the Voltage Sensor Domain and the Channel Pore

• मुख्य लेखकों: Julie I. R. Labau (लेखक), Matthew Alsaloum (लेखक), Mark Estacion (लेखक), Brian Tanaka (लेखक), Fadia B. Dib-Hajj (लेखक), Giuseppe Lauria (लेखक), Hubert J. M. Smeets (लेखक), Catharina G. Faber (लेखक), Sulayman Dib-Hajj (लेखक), Stephen G. Waxman (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2021-12-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Lacosamide, developed as an anti-epileptic drug, has been used for the treatment of pain. Unlike typical anticonvulsants and local anesthetics which enhance fast-inactivation and bind within the pore of sodium channels, lacosamide enhances slow-inactivation of these channels, suggesting different bi...