Blockade of the Notch1/Jagged1 pathway in Kupffer cells aggravates ischemia-reperfusion injury of orthotopic liver transplantation in mice

• Автори: He Bai (Автор), Jian Wen (Автор), Jian-Ping Gong (Автор), Hao Wu (Автор), Fang-Chao Yuan (Автор), Ding Cao (Автор), Ya-Kun Wu (Автор), Xing Lai (Автор), Meng-Hao Wang (Автор)
• Формат: Книга
• Опубліковано: Taylor & Francis Group, 2019-05-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Liver ischemia-reperfusion injury (IRI) represents a risk factor for early graft dysfunction and an obstacle to expanding donor pool in orthotopic liver transplantation (OLT). Kupffer cells (KCs) are the largest antigen-presenting cell (APC) group and the primary modulators of inflammation in liver...