Blockade of the Notch1/Jagged1 pathway in Kupffer cells aggravates ischemia-reperfusion injury of orthotopic liver transplantation in mice

• Main Authors: He Bai (Author), Jian Wen (Author), Jian-Ping Gong (Author), Hao Wu (Author), Fang-Chao Yuan (Author), Ding Cao (Author), Ya-Kun Wu (Author), Xing Lai (Author), Meng-Hao Wang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Liver ischemia-reperfusion injury (IRI) represents a risk factor for early graft dysfunction and an obstacle to expanding donor pool in orthotopic liver transplantation (OLT). Kupffer cells (KCs) are the largest antigen-presenting cell (APC) group and the primary modulators of inflammation in liver...