Blockade of the Notch1/Jagged1 pathway in Kupffer cells aggravates ischemia-reperfusion injury of orthotopic liver transplantation in mice

• Autori principali: He Bai (Autore), Jian Wen (Autore), Jian-Ping Gong (Autore), Hao Wu (Autore), Fang-Chao Yuan (Autore), Ding Cao (Autore), Ya-Kun Wu (Autore), Xing Lai (Autore), Meng-Hao Wang (Autore)
• Natura: Libro
• Pubblicazione: Taylor & Francis Group, 2019-05-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Liver ischemia-reperfusion injury (IRI) represents a risk factor for early graft dysfunction and an obstacle to expanding donor pool in orthotopic liver transplantation (OLT). Kupffer cells (KCs) are the largest antigen-presenting cell (APC) group and the primary modulators of inflammation in liver...