NGS-based accurate and efficient detection of circulating cell-free mitochondrial DNA in cancer patients

• Main Authors: Yang Liu (Author), Kaixiang Zhou (Author), Shanshan Guo (Author), Yang Wang (Author), Xiaoying Ji (Author), Qing Yuan (Author), Liping Su (Author), Xu Guo (Author), Xiwen Gu (Author), Jinliang Xing (Author)
• Format: Book
• Published: Elsevier, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mitochondrial DNA (mtDNA) mutations are closely implicated in the pathogenesis of multiple cancers, making circulating cell-free mtDNA (ccf-mtDNA) as a potential non-invasive tumor biomarker. However, an effective approach to comprehensively profile ccf-mtDNA mutations is still lacking. In this stud...