PKA phosphorylation of Cav1.2 channel modulates the interaction of calmodulin with the C terminal tail of the channel

• Glavni autori: Ming Lei (Autor), Jianjun Xu (Autor), Qinghua Gao (Autor), Etsuko Minobe (Autor), Masaki Kameyama (Autor), Liying Hao (Autor)
• Format: Knjiga
• Izdano: Elsevier, 2018-06-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Activity of cardiac Cav1.2 channels is enhanced by cyclic AMP-PKA signaling. In this study, we studied the effects of PKA phosphorylation on the binding of calmodulin to the fragment peptide of the proximal C-terminal tail of α1C subunit (CT1, a.a. 1509-1789 of guinea-pig). In the pull-down assay, i...