Antagomirs Targeting MiroRNA-134 Attenuates Epilepsy in Rats through Regulation of Oxidative Stress, Mitochondrial Functions and Autophagy

• Main Authors: Jiahang Sun (Author), Xiaoying Gao (Author), Dawei Meng (Author), Yang Xu (Author), Xichun Wang (Author), Xin Gu (Author), Mian Guo (Author), Xiaodong Shao (Author), Hongwen Yan (Author), Chuanlu Jiang (Author), Yongri Zheng (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The effects of the existing anti-epileptic drugs are unsatisfactory to almost one third of epileptic patients. MiR-134 antagomirs prevent pilocarpine-induced status epilepticus. In this study, a lithium chloride-pilocarpine-induced status epilepticus model was established and treated with intracereb...