Antagomirs Targeting MiroRNA-134 Attenuates Epilepsy in Rats through Regulation of Oxidative Stress, Mitochondrial Functions and Autophagy

• मुख्य लेखकों: Jiahang Sun (लेखक), Xiaoying Gao (लेखक), Dawei Meng (लेखक), Yang Xu (लेखक), Xichun Wang (लेखक), Xin Gu (लेखक), Mian Guo (लेखक), Xiaodong Shao (लेखक), Hongwen Yan (लेखक), Chuanlu Jiang (लेखक), Yongri Zheng (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2017-08-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

The effects of the existing anti-epileptic drugs are unsatisfactory to almost one third of epileptic patients. MiR-134 antagomirs prevent pilocarpine-induced status epilepticus. In this study, a lithium chloride-pilocarpine-induced status epilepticus model was established and treated with intracereb...