Glasdegib Dimaleate: Synthesis, Characterization and Comparison of Its Properties with Monomaleate Analogue

• Glavni autori: Boris Peklar (Autor), Franc Perdih (Autor), Damjan Makuc (Autor), Janez Plavec (Autor), Jérôme Cluzeau (Autor), Zoran Kitanovski (Autor), Zdenko Časar (Autor)
• Format: Knjiga
• Izdano: MDPI AG, 2022-08-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Glasdegib is a recently approved drug for the treatment of acute myeloid leukemia. It is formulated and marketed in monomaleate salt form. In our investigation, we were able to prepare a glasdegib dimaleate form, which could, in theory, exist in double-salt form or as a mixture of salt and co-crysta...