Glasdegib Dimaleate: Synthesis, Characterization and Comparison of Its Properties with Monomaleate Analogue

• Hauptverfasser: Boris Peklar (Verfasst von), Franc Perdih (Verfasst von), Damjan Makuc (Verfasst von), Janez Plavec (Verfasst von), Jérôme Cluzeau (Verfasst von), Zoran Kitanovski (Verfasst von), Zdenko Časar (Verfasst von)
• Format: Buch
• Veröffentlicht: MDPI AG, 2022-08-01T00:00:00Z.
• Schlagworte: article
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Glasdegib is a recently approved drug for the treatment of acute myeloid leukemia. It is formulated and marketed in monomaleate salt form. In our investigation, we were able to prepare a glasdegib dimaleate form, which could, in theory, exist in double-salt form or as a mixture of salt and co-crysta...