Inhibition of Autophagy In Vivo Extends Methamphetamine Toxicity to Mesencephalic Cell Bodies

• Main Authors: Michela Ferrucci (Author), Francesca Biagioni (Author), Carla L. Busceti (Author), Chiara Vidoni (Author), Roberta Castino (Author), Ciro Isidoro (Author), Larisa Ryskalin (Author), Alessandro Frati (Author), Stefano Puglisi-Allegra (Author), Francesco Fornai (Author)
• Format: Book
• Published: MDPI AG, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Methamphetamine (METH) is a widely abused psychostimulant and a stress-inducing compound, which leads to neurotoxicity for nigrostriatal dopamine (DA) terminals in rodents and primates including humans. In vitro studies indicate that autophagy is a strong modulator of METH toxicity. In detail, suppr...