Histone lysine demethylase inhibition reprograms prostate cancer metabolism and mechanics
Objective: Aberrant activity of androgen receptor (AR) is the primary cause underlying development and progression of prostate cancer (PCa) and castration-resistant PCa (CRPC). Androgen signaling regulates gene transcription and lipid metabolism, facilitating tumor growth and therapy resistance in e...
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Elsevier,
2022-10-01T00:00:00Z.
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