Histone lysine demethylase inhibition reprograms prostate cancer metabolism and mechanics

• Main Authors: Ugo Chianese (Author), Chiara Papulino (Author), Eugenia Passaro (Author), Tom MJ. Evers (Author), Mehrad Babaei (Author), Antonella Toraldo (Author), Tommaso De Marchi (Author), Emma Niméus (Author), Vincenzo Carafa (Author), Maria Maddalena Nicoletti (Author), Nunzio Del Gaudio (Author), Nunzia Iaccarino (Author), Antonio Randazzo (Author), Dante Rotili (Author), Antonello Mai (Author), Salvatore Cappabianca (Author), Alireza Mashaghi (Author), Fortunato Ciardiello (Author), Lucia Altucci (Author), Rosaria Benedetti (Author)
• Format: Book
• Published: Elsevier, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Aberrant activity of androgen receptor (AR) is the primary cause underlying development and progression of prostate cancer (PCa) and castration-resistant PCa (CRPC). Androgen signaling regulates gene transcription and lipid metabolism, facilitating tumor growth and therapy resistance in e...