Atorvastatin and Conditioned Media from Atorvastatin-Treated Human Hematopoietic Stem/Progenitor-Derived Cells Show Proangiogenic Activity In Vitro but Not In Vivo

• Main Authors: Witold N. Nowak (Author), Hevidar Taha (Author), Joanna Markiewicz (Author), Neli Kachamakova-Trojanowska (Author), Jacek Stępniewski (Author), Damian Klóska (Author), Urszula Florczyk-Soluch (Author), Rafał Niżankowski (Author), Marzena Frołow (Author), Zbigniew Walter (Author), Józef Dulak (Author), Alicja Józkowicz (Author)
• Format: Book
• Published: Hindawi Limited, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Myeloid angiogenic cells (MAC) derive from hematopoietic stem/progenitor cells (HSPCs) that are mobilized from the bone marrow. They home to sites of neovascularization and contribute to angiogenesis by production of paracrine factors. The number and function of proangiogenic cells are impaired in p...