Sildenafil improves exercise capacity in patients with cystic fibrosis: a proof-of-concept clinical trial

• Автори: Paula Rodriguez-Miguelez (Автор), Haruki Ishii (Автор), Nichole Seigler (Автор), Reva Crandall (Автор), Jeffrey Thomas (Автор), Caralee Forseen (Автор), Kathleen T. McKie (Автор), Ryan A. Harris (Автор)
• Формат: Книга
• Опубліковано: SAGE Publishing, 2019-11-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Background: Exercise intolerance is a common phenotype observed in patients with cystic fibrosis (CF). Treatment with sildenafil, a phosphodiesterase type 5 (PDE5) inhibitor, has previously been shown to improve exercise capacity (VO 2 peak) in other patient populations. Thus, the present study soug...