CaMKII-Dependent Contractile Dysfunction and Pro-Arrhythmic Activity in a Mouse Model of Obstructive Sleep Apnea

• Main Authors: Philipp Hegner (Author), Simon Lebek (Author), Benedikt Schaner (Author), Florian Ofner (Author), Mathias Gugg (Author), Lars Siegfried Maier (Author), Michael Arzt (Author), Stefan Wagner (Author)
• Format: Book
• Published: MDPI AG, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Left ventricular contractile dysfunction and arrhythmias frequently occur in patients with sleep-disordered breathing (SDB). The CaMKII-dependent dysregulation of cellular Ca homeostasis has recently been described in SDB patients, but these studies only partly explain the mechanism and are limited...