Influence of Single Nucleotide Polymorphisms on Rifampin Pharmacokinetics in Tuberculosis Patients

• Үндсэн зохиолчид: Levin Thomas (Зохиогч), Sonal Sekhar Miraj (Зохиогч), Mallayasamy Surulivelrajan (Зохиогч), Muralidhar Varma (Зохиогч), Chidananda S. V. Sanju (Зохиогч), Mahadev Rao (Зохиогч)
• Формат: Ном
• Хэвлэсэн: MDPI AG, 2020-06-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Rifampin (RF) is metabolized in the liver into an active metabolite 25-desacetylrifampin and excreted almost equally via biliary and renal routes. Various influx and efflux transporters influence RF disposition during hepatic uptake and biliary excretion. Evidence has also shown that Vitamin D defic...