Two different pathogenic mechanisms, dying-back axonal neuropathy and pancreatic senescence, are present in the YG8R mouse model of Friedreich's ataxia

• Main Authors: Belén Mollá (Author), Fátima Riveiro (Author), Arantxa Bolinches-Amorós (Author), Diana C. Muñoz-Lasso (Author), Francesc Palau (Author), Pilar González-Cabo (Author)
• Format: Book
• Published: The Company of Biologists, 2016-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Frataxin (FXN) deficiency causes Friedreich's ataxia (FRDA), a multisystem disorder with neurological and non-neurological symptoms. FRDA pathophysiology combines developmental and degenerative processes of dorsal root ganglia (DRG), sensory nerves, dorsal columns and other central nervous stru...