Two different pathogenic mechanisms, dying-back axonal neuropathy and pancreatic senescence, are present in the YG8R mouse model of Friedreich's ataxia

• मुख्य लेखकों: Belén Mollá (लेखक), Fátima Riveiro (लेखक), Arantxa Bolinches-Amorós (लेखक), Diana C. Muñoz-Lasso (लेखक), Francesc Palau (लेखक), Pilar González-Cabo (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: The Company of Biologists, 2016-06-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Frataxin (FXN) deficiency causes Friedreich's ataxia (FRDA), a multisystem disorder with neurological and non-neurological symptoms. FRDA pathophysiology combines developmental and degenerative processes of dorsal root ganglia (DRG), sensory nerves, dorsal columns and other central nervous stru...