The frequency of TP53 R72P and MDM2 309T>G polymorphisms in Iranian infertile men with spermatogenetic failure: A case-control study

• Main Authors: Zeinab Ebrahim Abadi (Author), Maryam Khademi Bami (Author), Maryam Golzadeh (Author), Seyed Mehdi Kalantar (Author), Mohammad Hasan Sheikhha (Author)
• Format: Book
• Published: Shahid Sadoughi University of Medical Sciences, 2018-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Tumor protein p53 (TP53) is a tumor suppressor transcriptional regulator protein which plays a critical role in the spermatogenesis. One of the most important regulators of p53 is Murine double minute 2 (MDM2), which acts as a negative regulator of the p53 pathway. Based on the key role...