The frequency of TP53 R72P and MDM2 309T>G polymorphisms in Iranian infertile men with spermatogenetic failure: A case-control study

• 主要な著者: Zeinab Ebrahim Abadi (著者), Maryam Khademi Bami (著者), Maryam Golzadeh (著者), Seyed Mehdi Kalantar (著者), Mohammad Hasan Sheikhha (著者)
• フォーマット: 図書
• 出版事項: Shahid Sadoughi University of Medical Sciences, 2018-08-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Background: Tumor protein p53 (TP53) is a tumor suppressor transcriptional regulator protein which plays a critical role in the spermatogenesis. One of the most important regulators of p53 is Murine double minute 2 (MDM2), which acts as a negative regulator of the p53 pathway. Based on the key role...