Redox-responsive biocompatible nanocarriers based on novel heparosan polysaccharides for intracellular anticancer drug delivery

• Main Authors: Lipeng Qiu (Author), Lu Ge (Author), Miaomiao Long (Author), Jing Mao (Author), Kamel S. Ahmed (Author), Xiaotian Shan (Author), Huijie Zhang (Author), Li Qin (Author), Guozhong Lv (Author), Jinghua Chen (Author)
• Format: Book
• Published: Elsevier, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Heparosan is a natural precursor of heparin biosynthesis in mammals. It is stable in blood circulation but can be degraded in lysosomes, showing good biocompatibility and long circulation features. So heparosan can be designed as anticancer drug carriers to increase tumor selectivity and improve the...