Decoy Receptor 3 Promotes Preosteoclast Cell Death via Reactive Oxygen Species-Induced Fas Ligand Expression and the IL-1α/IL-1 Receptor Antagonist Pathway

• Main Authors: Yi-Jen Peng (Author), Ching-Tsung Peng (Author), Yi-Hsuan Lin (Author), Gu-Jiun Lin (Author), Shing-Hwa Huang (Author), Shyi-Jou Chen (Author), Huey-Kang Sytwu (Author), Chia-Pi Cheng (Author)
• Format: Book
• Published: Hindawi Limited, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose. Interleukin-1α (IL-1α) is a potent cytokine that plays a role in inflammatory arthritis and bone loss. Decoy receptor 3 (DCR3) is an immune modulator of monocytes and macrophages. The aim of this study was to investigate the mechanism of DCR3 in IL-1α-induced osteoclastogenesis. Methods. We...