Decoy Receptor 3 Promotes Preosteoclast Cell Death via Reactive Oxygen Species-Induced Fas Ligand Expression and the IL-1α/IL-1 Receptor Antagonist Pathway

• Главные авторы: Yi-Jen Peng (Автор), Ching-Tsung Peng (Автор), Yi-Hsuan Lin (Автор), Gu-Jiun Lin (Автор), Shing-Hwa Huang (Автор), Shyi-Jou Chen (Автор), Huey-Kang Sytwu (Автор), Chia-Pi Cheng (Автор)
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• Опубликовано: Hindawi Limited, 2020-01-01T00:00:00Z.
• Предметы: article
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Purpose. Interleukin-1α (IL-1α) is a potent cytokine that plays a role in inflammatory arthritis and bone loss. Decoy receptor 3 (DCR3) is an immune modulator of monocytes and macrophages. The aim of this study was to investigate the mechanism of DCR3 in IL-1α-induced osteoclastogenesis. Methods. We...