Decoy Receptor 3 Promotes Preosteoclast Cell Death via Reactive Oxygen Species-Induced Fas Ligand Expression and the IL-1α/IL-1 Receptor Antagonist Pathway

• Glavni autori: Yi-Jen Peng (Autor), Ching-Tsung Peng (Autor), Yi-Hsuan Lin (Autor), Gu-Jiun Lin (Autor), Shing-Hwa Huang (Autor), Shyi-Jou Chen (Autor), Huey-Kang Sytwu (Autor), Chia-Pi Cheng (Autor)
• Format: Knjiga
• Izdano: Hindawi Limited, 2020-01-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Purpose. Interleukin-1α (IL-1α) is a potent cytokine that plays a role in inflammatory arthritis and bone loss. Decoy receptor 3 (DCR3) is an immune modulator of monocytes and macrophages. The aim of this study was to investigate the mechanism of DCR3 in IL-1α-induced osteoclastogenesis. Methods. We...