BACE2 suppression in mice aggravates the adverse metabolic consequences of an obesogenic diet

• Main Authors: Daniela Díaz-Catalán (Author), Gema Alcarraz-Vizán (Author), Carlos Castaño (Author), Sara de Pablo (Author), Júlia Rodríguez-Comas (Author), Antonio Fernández-Pérez (Author), Mario Vallejo (Author), Sara Ramírez (Author), Marc Claret (Author), Marcelina Parrizas (Author), Anna Novials (Author), Joan-Marc Servitja (Author)
• Format: Book
• Published: Elsevier, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Pancreatic β-cell dysfunction is a central feature in the pathogenesis of type 2 diabetes (T2D). Accumulating evidence indicates that β-site APP-cleaving enzyme 2 (BACE2) inhibition exerts a beneficial effect on β-cells in different models of T2D. Thus, targeting BACE2 may represent a pot...