BACE2 suppression in mice aggravates the adverse metabolic consequences of an obesogenic diet

• मुख्य लेखकों: Daniela Díaz-Catalán (लेखक), Gema Alcarraz-Vizán (लेखक), Carlos Castaño (लेखक), Sara de Pablo (लेखक), Júlia Rodríguez-Comas (लेखक), Antonio Fernández-Pérez (लेखक), Mario Vallejo (लेखक), Sara Ramírez (लेखक), Marc Claret (लेखक), Marcelina Parrizas (लेखक), Anna Novials (लेखक), Joan-Marc Servitja (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2021-11-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Objective: Pancreatic β-cell dysfunction is a central feature in the pathogenesis of type 2 diabetes (T2D). Accumulating evidence indicates that β-site APP-cleaving enzyme 2 (BACE2) inhibition exerts a beneficial effect on β-cells in different models of T2D. Thus, targeting BACE2 may represent a pot...