BACE2 suppression in mice aggravates the adverse metabolic consequences of an obesogenic diet

• Główni autorzy: Daniela Díaz-Catalán (Autor), Gema Alcarraz-Vizán (Autor), Carlos Castaño (Autor), Sara de Pablo (Autor), Júlia Rodríguez-Comas (Autor), Antonio Fernández-Pérez (Autor), Mario Vallejo (Autor), Sara Ramírez (Autor), Marc Claret (Autor), Marcelina Parrizas (Autor), Anna Novials (Autor), Joan-Marc Servitja (Autor)
• Format: Książka
• Wydane: Elsevier, 2021-11-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Objective: Pancreatic β-cell dysfunction is a central feature in the pathogenesis of type 2 diabetes (T2D). Accumulating evidence indicates that β-site APP-cleaving enzyme 2 (BACE2) inhibition exerts a beneficial effect on β-cells in different models of T2D. Thus, targeting BACE2 may represent a pot...