Liver-specific Prkn knockout mice are more susceptible to diet-induced hepatic steatosis and insulin resistance

• 主要な著者: Lia R. Edmunds (著者), Bingxian Xie (著者), Amanda M. Mills (著者), Brydie R. Huckestein (著者), Ramya Undamatla (著者), Anjana Murali (著者), Martha M. Pangburn (著者), James Martin (著者), Ian Sipula (著者), Brett A. Kaufman (著者), Iain Scott (著者), Michael J. Jurczak (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2020-11-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Objective: PARKIN is an E3 ubiquitin ligase that regulates mitochondrial quality control through a process called mitophagy. Recent human and rodent studies suggest that loss of hepatic mitophagy may occur during the pathogenesis of obesity-associated fatty liver and contribute to changes in mitocho...