Liver-specific Prkn knockout mice are more susceptible to diet-induced hepatic steatosis and insulin resistance

• मुख्य लेखकों: Lia R. Edmunds (लेखक), Bingxian Xie (लेखक), Amanda M. Mills (लेखक), Brydie R. Huckestein (लेखक), Ramya Undamatla (लेखक), Anjana Murali (लेखक), Martha M. Pangburn (लेखक), James Martin (लेखक), Ian Sipula (लेखक), Brett A. Kaufman (लेखक), Iain Scott (लेखक), Michael J. Jurczak (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2020-11-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Objective: PARKIN is an E3 ubiquitin ligase that regulates mitochondrial quality control through a process called mitophagy. Recent human and rodent studies suggest that loss of hepatic mitophagy may occur during the pathogenesis of obesity-associated fatty liver and contribute to changes in mitocho...