Liver-specific Prkn knockout mice are more susceptible to diet-induced hepatic steatosis and insulin resistance

• Main Authors: Lia R. Edmunds (Author), Bingxian Xie (Author), Amanda M. Mills (Author), Brydie R. Huckestein (Author), Ramya Undamatla (Author), Anjana Murali (Author), Martha M. Pangburn (Author), James Martin (Author), Ian Sipula (Author), Brett A. Kaufman (Author), Iain Scott (Author), Michael J. Jurczak (Author)
• Format: Book
• Published: Elsevier, 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: PARKIN is an E3 ubiquitin ligase that regulates mitochondrial quality control through a process called mitophagy. Recent human and rodent studies suggest that loss of hepatic mitophagy may occur during the pathogenesis of obesity-associated fatty liver and contribute to changes in mitocho...