Liver-specific Prkn knockout mice are more susceptible to diet-induced hepatic steatosis and insulin resistance

• Главные авторы: Lia R. Edmunds (Автор), Bingxian Xie (Автор), Amanda M. Mills (Автор), Brydie R. Huckestein (Автор), Ramya Undamatla (Автор), Anjana Murali (Автор), Martha M. Pangburn (Автор), James Martin (Автор), Ian Sipula (Автор), Brett A. Kaufman (Автор), Iain Scott (Автор), Michael J. Jurczak (Автор)
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• Опубликовано: Elsevier, 2020-11-01T00:00:00Z.
• Предметы: article
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Objective: PARKIN is an E3 ubiquitin ligase that regulates mitochondrial quality control through a process called mitophagy. Recent human and rodent studies suggest that loss of hepatic mitophagy may occur during the pathogenesis of obesity-associated fatty liver and contribute to changes in mitocho...