Enantiomeric characterization and structure elucidation of Otamixaban

• Main Authors: Jian Shen (Author), Jiping Yang (Author), Winfried Heyse (Author), Harald Schweitzer (Author), Norbert Nagel (Author), Doris Andert (Author), Chengyue Zhu (Author), Vincent Morrison (Author), Gregory A. Nemeth (Author), Teng-Man Chen (Author), Zhicheng Zhao (Author), Timothy A. Ayers (Author), Yong-Mi Choi (Author)
• Format: Book
• Published: Elsevier, 2014-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Otamixaban is a potent (Ki=0.5 nM) fXa inhibitor currently in late-stage clinical development at Sanofi for the management of acute coronary syndrome. Being unproductive in obtaining a suitable crystal of Otamixaban, the required enantiomeric characterization has been accomplished using vibrational...