Enantiomeric characterization and structure elucidation of Otamixaban

• Autori principali: Jian Shen (Autore), Jiping Yang (Autore), Winfried Heyse (Autore), Harald Schweitzer (Autore), Norbert Nagel (Autore), Doris Andert (Autore), Chengyue Zhu (Autore), Vincent Morrison (Autore), Gregory A. Nemeth (Autore), Teng-Man Chen (Autore), Zhicheng Zhao (Autore), Timothy A. Ayers (Autore), Yong-Mi Choi (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2014-06-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Otamixaban is a potent (Ki=0.5 nM) fXa inhibitor currently in late-stage clinical development at Sanofi for the management of acute coronary syndrome. Being unproductive in obtaining a suitable crystal of Otamixaban, the required enantiomeric characterization has been accomplished using vibrational...