An Enteric-Coated Polyelectrolyte Nanocomplex Delivers Insulin in Rat Intestinal Instillations When Combined with a Permeation Enhancer

• Автори: Svenja Sladek (Автор), Fiona McCartney (Автор), Mena Eskander (Автор), David J. Dunne (Автор), Maria Jose Santos-Martinez (Автор), Federico Benetti (Автор), Lidia Tajber (Автор), David J. Brayden (Автор)
• Формат: Книга
• Опубліковано: MDPI AG, 2020-03-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

The use of nanocarriers is being researched to achieve oral peptide delivery. Insulin-associated anionic polyelectrolyte nanoparticle complexes (PECs) were formed that comprised hyaluronic acid and chitosan in an optimum mass mixing ratio of 5:1 (MR 5), followed by coating with a pH-dependent polyme...