An Enteric-Coated Polyelectrolyte Nanocomplex Delivers Insulin in Rat Intestinal Instillations When Combined with a Permeation Enhancer

• Váldodahkkit: Svenja Sladek (Dahkki), Fiona McCartney (Dahkki), Mena Eskander (Dahkki), David J. Dunne (Dahkki), Maria Jose Santos-Martinez (Dahkki), Federico Benetti (Dahkki), Lidia Tajber (Dahkki), David J. Brayden (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: MDPI AG, 2020-03-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

The use of nanocarriers is being researched to achieve oral peptide delivery. Insulin-associated anionic polyelectrolyte nanoparticle complexes (PECs) were formed that comprised hyaluronic acid and chitosan in an optimum mass mixing ratio of 5:1 (MR 5), followed by coating with a pH-dependent polyme...