MAP3K1 function is essential for cytoarchitecture of the mouse organ of Corti and survival of auditory hair cells

• Główni autorzy: Rizwan Yousaf (Autor), Qinghang Meng (Autor), Robert B. Hufnagel (Autor), Ying Xia (Autor), Chandrakala Puligilla (Autor), Zubair M. Ahmed (Autor), Saima Riazuddin (Autor)
• Format: Książka
• Wydane: The Company of Biologists, 2015-12-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

MAP3K1 is a serine/threonine kinase that is activated by a diverse set of stimuli and exerts its effect through various downstream effecter molecules, including JNK, ERK1/2 and p38. In humans, mutant alleles of MAP3K1 are associated with 46,XY sex reversal. Until recently, the only phenotype observe...