MAP3K1 function is essential for cytoarchitecture of the mouse organ of Corti and survival of auditory hair cells

• Main Authors: Rizwan Yousaf (Author), Qinghang Meng (Author), Robert B. Hufnagel (Author), Ying Xia (Author), Chandrakala Puligilla (Author), Zubair M. Ahmed (Author), Saima Riazuddin (Author)
• Format: Book
• Published: The Company of Biologists, 2015-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

MAP3K1 is a serine/threonine kinase that is activated by a diverse set of stimuli and exerts its effect through various downstream effecter molecules, including JNK, ERK1/2 and p38. In humans, mutant alleles of MAP3K1 are associated with 46,XY sex reversal. Until recently, the only phenotype observe...