Betulinic Acid Attenuates Osteoarthritis via Limiting NLRP3 Inflammasome Activation to Decrease Interleukin-1β Maturation and Secretion

• Main Authors: Bo Liu (Author), Yanglin Wu (Author), Ting Liang (Author), Yunlong Zhou (Author), Guangdong Chen (Author), Jiaheng He (Author), Chenchen Ji (Author), Peixin Liu (Author), Chenhui Zhang (Author), Jun Lin (Author), Kece Shi (Author), Zongping Luo (Author), Naicheng Liu (Author), Xinlin Su (Author)
• Format: Book
• Published: Hindawi Limited, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction. Osteoarthritis (OA) is the most common degenerative joint disorder. Prior studies revealed that activation of NLRP3 inflammasome could promote the activation and secretion of interleukin-1β (IL-1β), which has an adverse effect on the progression of OA. Betulinic acid (BA) is a compound...