Antimicrobial Evaluation of Sulfonamides after Coupling with Thienopyrimidine Coplanar Structure

• Main Authors: Elshaymaa I. Elmongy (Author), Wejdan S. Alanazi (Author), Alhanouf I. Aldawsari (Author), Asma A. Alfaouri (Author), Reem Binsuwaidan (Author)
• Format: Book
• Published: MDPI AG, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This work describes the design and synthesis of three series of hybrids of thienopyrimidines and sulfonamides. Dihydrofolate reductase enzyme was selected as a target for the in-silico screening of the synthesized thienopyrimidine-sulfonamide hybrid as an antibacterial, while squalene epoxidase was...