Morphine Antinociception Restored by Use of Methadone in the Morphine-Resistant Inflammatory Pain State
The antinociceptive effect of methadone in the morphine-resistant inflammatory pain state was described in the paw-withdrawal test using the complete Freund's adjuvant (CFA)-induced mouse inflammatory pain model. After intraplantar (i.pl.) injection of CFA, thermal hyperalgesia was observed in...
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Frontiers Media S.A.,
2020-12-01T00:00:00Z.
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