siRNA-optimized Modifications for Enhanced In Vivo Activity

• Autores principales: Denise M Kenski (Autor), Gabor Butora (Autor), Aarron T Willingham (Autor), Abby J Cooper (Autor), Wenlang Fu (Autor), Ning Qi (Autor), Ferdie Soriano (Autor), Ian W Davies (Autor), W Michael Flanagan (Autor)
• Formato: Libro
• Publicado: Elsevier, 2012-01-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Current modifications used in small interfering RNAs (siRNAs), such as 2'-methoxy (2'-OMe) and 2'-fluoro (2'-F), improve stability, specificity or immunogenic properties but do not improve potency. These modifications were previously designed for use in antisense and not siRNA. W...