siRNA-optimized Modifications for Enhanced In Vivo Activity

• Main Authors: Denise M Kenski (Author), Gabor Butora (Author), Aarron T Willingham (Author), Abby J Cooper (Author), Wenlang Fu (Author), Ning Qi (Author), Ferdie Soriano (Author), Ian W Davies (Author), W Michael Flanagan (Author)
• Format: Book
• Published: Elsevier, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Current modifications used in small interfering RNAs (siRNAs), such as 2'-methoxy (2'-OMe) and 2'-fluoro (2'-F), improve stability, specificity or immunogenic properties but do not improve potency. These modifications were previously designed for use in antisense and not siRNA. W...