siRNA-optimized Modifications for Enhanced In Vivo Activity

• Главные авторы: Denise M Kenski (Автор), Gabor Butora (Автор), Aarron T Willingham (Автор), Abby J Cooper (Автор), Wenlang Fu (Автор), Ning Qi (Автор), Ferdie Soriano (Автор), Ian W Davies (Автор), W Michael Flanagan (Автор)
• Формат: ‌
• Опубликовано: Elsevier, 2012-01-01T00:00:00Z.
• Предметы: article
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Current modifications used in small interfering RNAs (siRNAs), such as 2'-methoxy (2'-OMe) and 2'-fluoro (2'-F), improve stability, specificity or immunogenic properties but do not improve potency. These modifications were previously designed for use in antisense and not siRNA. W...