Preparing anti-SARS-CoV-2 agent EIDD-2801 by a practical and scalable approach, and quick evaluation via machine learning

• Prif Awduron: Zhen Qin (Awdur), Bin Dong (Awdur), Renbing Wang (Awdur), Dechun Huang (Awdur), Jubo Wang (Awdur), Xi Feng (Awdur), Jinlei Bian (Awdur), Zhiyu Li (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Elsevier, 2021-11-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

EIDD-2801 is an orally bioavailable prodrug, which will be applied for emergency use authorization from the U.S. Food and Drug Administration for the treatment of COVID-19. To investigate the optimal parameters, EIDD-2801 was optimized via a four-step synthesis with high purity of 99.9%. The hydroxy...