LEAP2 deletion in mice enhances ghrelin's actions as an orexigen and growth hormone secretagogue

• Main Authors: Kripa Shankar (Author), Nathan P. Metzger (Author), Omprakash Singh (Author), Bharath K. Mani (Author), Sherri Osborne-Lawrence (Author), Salil Varshney (Author), Deepali Gupta (Author), Sean B. Ogden (Author), Shota Takemi (Author), Corine P. Richard (Author), Karabi Nandy (Author), Chen Liu (Author), Jeffrey M. Zigman (Author)
• Format: Book
• Published: Elsevier, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The hormone liver-expressed antimicrobial peptide-2 (LEAP2) is a recently identified antagonist and an inverse agonist of the growth hormone secretagogue receptor (GHSR). GHSR's other well-known endogenous ligand, acyl-ghrelin, increases food intake, body weight, and GH secretion and...