Ancestry and TPMT-VNTR Polymorphism: Relationship with Hematological Toxicity in Uruguayan Patients with Acute Lymphoblastic Leukemia

• मुख्य लेखकों: Gabriela Burgueño-Rodríguez (लेखक), Yessika Méndez (लेखक), Natalia Olano (लेखक), Agustín Dabezies (लेखक), Bernardo Bertoni (लेखक), Jorge Souto (लेखक), Luis Castillo (लेखक), Julio da Luz (लेखक), Ana María Soler (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2020-11-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

6-Mercaptopurine (6-MP) is a thiopurine drug widely used in childhood acute lymphoblastic leukemia (ALL) therapy. Genes such as TPMT and NUDT15 have an outstanding role in 6-MP metabolism. Mutations in both genes explain a significant portion of hematological toxicities suffered by ALL Uruguayan ped...