Ancestry and TPMT-VNTR Polymorphism: Relationship with Hematological Toxicity in Uruguayan Patients with Acute Lymphoblastic Leukemia

• Main Authors: Gabriela Burgueño-Rodríguez (Author), Yessika Méndez (Author), Natalia Olano (Author), Agustín Dabezies (Author), Bernardo Bertoni (Author), Jorge Souto (Author), Luis Castillo (Author), Julio da Luz (Author), Ana María Soler (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

6-Mercaptopurine (6-MP) is a thiopurine drug widely used in childhood acute lymphoblastic leukemia (ALL) therapy. Genes such as TPMT and NUDT15 have an outstanding role in 6-MP metabolism. Mutations in both genes explain a significant portion of hematological toxicities suffered by ALL Uruguayan ped...